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In response to KITLG/SCF binding, KIT can activate several signaling pathways. CD117: a type I transmembrane protein present on hemopoietic progenitors, mast cells, melanocytes, spermatogonia, oocytes, and some natural killer cells; assists in signal transduction to transfected cell lines; expressed in colon carcinomas. Description. CD117 is a 145 kD protein tyrosine kinase also known as c-Kit. It is a receptor for stem cell factor or c-Kit ligand. CD117 is expressed on pluripotent hematopoietic progenitor cells (approximately 1-4% bone marrow cells), mast cells, and acute myeloid leukemia cells (AML).
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Leverantör: analysis of formalin-fixed and paraffin-embedded human skintissue using C Kit antibody Antigen: C Kit Friska upp och ge huden glow med Vitamin C Giddy Glow Kit. En rejält huduppfräschande present med peeling och sheet mask för alla tillfällen. Köp idag! Köp Best of Vitamin-C Face Skincare Kit från Pixi på Åhlens ✓ Öppet köp i 60 dagar ✓ Fri frakt och fri retur till varuhus ✓ Betala enkelt med c-kit Receptor. c-kit, p145. c-kit, Proto-Oncogene Protein. CD117 Antigen. CD117 Antigens.
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Hongyo T, Li T, Syaifudin M, Baskar R, Ikeda H, Kanakura Y, Aozasa K, Nomura T. Specific c-kit mutations in sinonasal natural killer/T-cell lymphoma in China and Japan. Cancer Res. 2000 May 1;60(9):2345-7. Citation on PubMed; Isozaki K, Terris B, Belghiti J, Schiffmann S, Hirota S, Vanderwinden JM.
Leverantör: analysis of formalin-fixed and paraffin-embedded human skintissue using C Kit antibody Antigen: C Kit Friska upp och ge huden glow med Vitamin C Giddy Glow Kit. En rejält huduppfräschande present med peeling och sheet mask för alla tillfällen. Köp idag! Köp Best of Vitamin-C Face Skincare Kit från Pixi på Åhlens ✓ Öppet köp i 60 dagar ✓ Fri frakt och fri retur till varuhus ✓ Betala enkelt med c-kit Receptor.
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Multiple transcript variants encoding different isoforms have been found for this gene.
CD117. CD117 (c-kit) is a transmembrane tyrosine kinase receptor that has been immunolocalized in various neoplasms, the most notable of which is gastrointestinal stromal tumors where c-kit is felt to be a relatively specific and sensitive immunohistochemical marker of gastrointestinal stromal tumors. c-Kit inhibitors (inhibiting targets of signaling pathways) used for various assays, some have entered clinical trials, which would be new cancer therapies.
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Se hela listan på fr.wikipedia.org Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. c-kit基因位于人染色体4q12-13,属于原癌基因,其产物是Ⅲ型酪氨酸激酶。C-KIT是酪氨酸激酶受体蛋白家族的重要成员之一,其作为干细胞因子的受体,可以通过一系列信号通路参与造血干细胞增殖分化的调控。 Joyetech EVIO C KitTo enter Contests, Subscribe to the newsletter here: https://mailchi.mp/djlsbvapes/subscribeBecome a member of the channel here: https://w Permanent hårt rebaseringsmaterial. För direktteknik.Metylmetakrylatfri. Neutral smak. The viral oncogene v-c-Kit was in 1986 identified as the transforming gene of Hardy-Zuckerman 4 feline sarcoma virus (hence its name c-Kit as in kitten) (25).
2021-04-10 · c-KIT is expressed in ovarian carcinoma and it is statistically correlated with chemotherapy resistance. REVIEW: Signal transduction though the KIT pathway in mast cells and involvement in MC activation and mediator release. c-kit gene mutation may play a significant role in the pathogenesis of GIST and also may be a prognostic marker.
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